Shiitake Mushroom


A strong 4:1 Shiitake Powder is used to compound for Mymmunity

Ingredient Details

Family‎: ‎Omphalotaceae

Genus‎: ‎Lentinula

Species‎: ‎L. edodes

Immune support

In human research, taking shiitake powder increased signs of immune stimulation, including natural killer cell and T cell activity. Based on saliva immunoglobulin levels, gut immunity was enhanced. Shiitake mushroom contains lentinan which has known immunostimulatory effects. Lentinan appears to enhance T-helper cells and stimulate interferon and various cytokines. It also increases the activity of natural killer cells and macrophages. In laboratory research these same effects may be seen with shiitake mushroom extract.

Other uses

Shiitake is also tonic and adaptogen, to increase energy, cure colds and treat poor circulation.
Other uses include HIV, hepatitis, post surgery immune enhancement and genital warts.

How it works

Shiitake mushroom contains chemicals that might stimulate the immune system. Lentinan is a polysaccharide isolated from the fruit body of shiitake mushroom. Lentinan stimulates the immune system and is used in combination with chemotherapy in the treatment of lung, stomach, skin, breast and colorectal cancer. Lenthionine inhibits platelet aggregation.


When taken by mouth: Shiitake mushroom is LIKELY SAFE when consumed in food amounts, but it is POSSIBLY UNSAFE in medicinal amounts. It can cause stomach discomfort, blood abnormalities, and skin swelling (inflammation). It might also cause an increased sensitivity to the sun, allergic skin reactions, and breathing problems.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if shiitake mushroom is safe to use when you are pregnant or breast-feeding. Stay on the safe side and avoid use.

"Auto-immune diseases" such as multiple sclerosis (MS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or other conditions: Shiitake mushroom might cause the immune system to become more active. This could increase the symptoms of auto-immune diseases. If you have one of these conditions, it’s best to avoid using shiitake mushroom.

A blood disorder called eosinophilia: Don't use shiitake mushroom if you have this condition. It might make eosinophilia worse.

Interactions with medications

Medications that decrease the immune system (Immunosuppressants)

Interaction Rating = Moderate Be cautious with this combination.

Talk to your health provider.

Shiitake mushroom seems to increase the activity of the immune system. Therefore, shiitake mushroom might decrease the effectiveness of medications that decrease immune system function.

Some medications that decrease immune system function include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Interactions with Herbs, Supplements, and Foods

There are no known interactions with herbs and supplements.

There are no known interactions with foods.


The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

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