Saccharomyces Boulardii

Proprietary Source

Gnosis Biootic® S. boulardii

Supplement Class

Yeast probiotic

Immune support

Research has found that S. boulardii has a bioregulatory effect on the intestinal flora helping to maintain a normal balance of friendly bacteria in the intestine that modulates immunity.

Other uses

It also support gut function under many conditions, including inflammatory bowel disease, irritable bowel syndrome and traveler’s diarrhoea.

Acne. Research shows that taking Saccharomyces boulardii by mouth helps improve the appearance of acne.

Diarrhea in people taking antibiotics (antibiotic-associated diarrhea). Most research shows that Saccharomyces boulardii can help prevent diarrhea in adults and children being treated with antibiotics. For every 9-13 patients treated with Saccharomyces boulardii during treatment with antibiotics, one less person will develop antibiotic-related diarrhea.

Infection of the gastrointestinal tract by bacteria called Clostridium difficile. Taking Saccharomyces boulardii along with antibiotics seems to help prevent Clostridium difficile-associated diarrhea from recurring in people with a history of recurrence. Taking Saccharomyces boulardii along with antibiotics also seems to help prevent first episodes of Clostridium difficile-associated diarrhea. But experts don't recommend using Saccharomyces for preventing first episodes.

A digestive tract infection that can lead to ulcers (Helicobacter pylori or H. pylori). Taking Saccharomyces boulardii by mouth along with standard H. pylori treatment helps treat this infection. About 12 people need to be treated with additional Saccharomyces boulardii for one patient who would otherwise remain infected to be cured. Taking Saccharomyces boulardii also helps prevent side effects such as diarrhea and nausea that occur with standard H. pylori treatment. This might help people finish their standard treatment for H. pylori.

Diarrhea in people with HIV/AIDS. Taking Saccharomyces boulardii by mouth appears to reduce diarrhea related to HIV.

Travelers' diarrhea. Taking Saccharomyces boulardii by mouth appears to prevent travelers' diarrhea.

How it works

Saccharomyces boulardii is called a "probiotic," a friendly organism that helps to fight off disease-causing organisms in the gut such as bacteria and yeast.

Biootic® S. boulardii is obtained through a proprietary patented process based on a less aggressive drying at controlled temperature and lower vacuum, allowing to preserve whole yeast cells and the content of water content unchanged over time, providing greater stability and delaying the yeast aging process, such as cell deterioration and product contamination.

Safety

When taken by mouth: Saccharomyces boulardii is LIKELY SAFE for most adults when taken by mouth for up to 15 months. It can cause gas in some people. Rarely, it might cause fungal infections that can spread through the bloodstream to the entire body (fungemia).

Special Precautions & Warnings:

Children: Saccharomyces boulardii is POSSIBLY SAFE for children when taken by mouth appropriately. However, diarrhea in children should be evaluated by a healthcare professional before using Saccharomyces boulardii.

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking Saccharomyces boulardii if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Elderly: The elderly might have an increased risk of fungal infection when taking Saccharomyces boulardii. Stay on the safe side and avoid use.

Weakened immune system: There is some concern that taking Saccharomyces boulardii might cause fungemia, which is the presence of yeast in the blood. The actual number of cases of Saccharomyces boulardii-related fungemia is hard to determine. However, the risk seems to be greatest for people who are very sick or who have weakened immune systems. In particular, people with catheters, those receiving tube feeding, and those being treated with multiple antibiotics or antibiotics that work on a wide variety of infections seem to be most at-risk. In many cases, fungemia resulted from catheter contamination by air, environmental surfaces, or hands that have been contaminated with Saccharomyces boulardii.

Yeast allergy: People with yeast allergy can be allergic to products containing Saccharomyces boulardii, and are best advised to avoid these products.

Interactions with medications

Medications for fungal infections (Antifungals)

Interaction Rating = Minor Be watchful with this combination.

Talk to your health provider.

Saccharomyces boulardii is a fungus. Medications for fungal infections help reduce fungus in and on the body. Taking Saccharomyces boulardii with medications for fungal infections can reduce the effectiveness of Saccharomyces boulardii.

Some medications for fungal infection include fluconazole (Diflucan), caspofungin (Cancidas), itraconazole (Sporanox) amphotericin (Ambisome), and others.

Interactions with Herbs, Supplements, and Foods

There are no known interactions with herbs and supplements.

There are no known interactions with foods.

References

Scarpignato C, Rampal P. Prevention and treatment of traveler's diarrhea: A clinical pharmacological approach. Chemotherapy 1995;41:48-81.

Bassetti S, Frei R, Zimmerli W. Fungemia with Saccharomyces cerevisiae after treatment with Saccharomyces boulardii. Am J Med 1998;105:71-2.

Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.

McCullough MJ, Clemons KV, McCusker JH, Stevens DA. Species identification and virulence attributes of Saccharomyces boulardii (nom. inval.). J Clin Microbiol 1998;36:2613-7.

McFarland LV. Saccharomyces boulardii is not Saccharomyces cerevisiae. Clin Infect Dis 1996;22:200-1.

Saavedra J. Probiotics and infectious diarrhea. Am J Gastroenterol 2000;95:S16-8.

Castagliuolo I, Riegler MF, Valenick L, et al. Saccharomyces boulardii protease inhibits the effects of clostridium difficile toxins A and B in human colonic mucosa. Infection and Immun 1999;67:302-7.

Bleichner G, Blehaut H, Mentec H, et al. Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. Intensive Care Med 1997;23:517-23.

Lewis SJ, Potts LF, Barry RE. The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhea in elderly patients. J Infect 1998;36:171-4.

Elmer GW, McFarland LV. Comment on the lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhea in elderly patients. J Infect 1998;37:307-8.

McFarland LV, Surawicz CM, Greenberg RN, et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 1994;271:1913-8.

McFarland LV, Surawicz CM, Greenberg RN, et al. Prevention of beta-lactam associated diarrhea by Saccharomyces boulardii compared with placebo. Am J Gastroenterol 1995;90:439-48.

Surawicz CM, McFarland LV, Elmer G, et al. Treatment of recurrent clostridium difficile colitis with vancomycin and Saccharomyces boulardii. Am J Gastroenterol 1989;84:1285-7.

Surawicz CM, Elmer GW, Speelman P, et al. Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: a prospective study. Gastroenterology 1989;96:981-8.

Buts JP, Corthier G, Delmee M. Saccharomyces boulardii for Clostridium difficile-associated enteropathies in infants. J Pediatr Gastroenterol Nutr 1993;16:419-25.

Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5.

Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.

Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.

Czerucka D, Roux I, Rampal P. Saccharomyces boulardii inhibits secretagogue-mediated adenosine 3',5'-cyclic monophosphate induction in intestinal cells. Gastroenterol 1994;106:65-72.

Krammer M, Karbach U. Antidiarrheal action of the yeast Saccharomyces boulardii in the rat small and large intestine by stimulating chloride absorption. Z Gastroenterol 1993;31:73-7.

Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22.

Weber G, Adamczyk A, Freytag S. [Treatment of acne with a yeast preparation]. Fortschr Med 1989;107:563-6.

Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5.

Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9.

Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34.

Muller J, Remus N, Harms KH. Mycoserological study of the treatment of paediatric cystic fibrosis patients with Saccharomyces boulardii (Saccharomyces cerevisiae Hansen CBS 5926). Mycoses 1995;38:119-23.

D'Souza AL, Rajkumar C, Cooke J, Bulpitt CJ. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 2002;324:1361.

Cremonini F, Di Caro S, Covino M, et al. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol 2002;97:2744-9.

Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80.

Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9.

McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006;101:812-22.

Guslandi M, Mezzi G, Sorghi M, Testoni PA. Saccharomyces boulardii in maintenance treatment of Crohn's disease. Dig Dis Sci 2000;45:1462-4.

Guslandi M, Giollo P, Testoni PA. A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol 2003;15:697-8.

Can M, Besirbellioglu BA, Avci IY, et al. Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: A prospective study. Med Sci Monit 2006;12:PI19-22.

Szajewska H, Mrukowicz J. Meta-analysis: non-pathogenic yeast Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther 2005;22:365-72.

Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34.

Johnston BC, Ma SSY, Goldenberg JZ, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea. Ann Intern Med 2012;157:878-8.

Surawicz, C. M., McFarland, L. V., Greenberg, R. N., Rubin, M., Fekety, R., Mulligan, M. E., Garcia, R. J., Brandmarker, S., Bowen, K., Borjal, D., and Elmer, G. W. The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin.Infect.Dis. 2000;31(4):1012-1017.

Shanahan, F. Probiotics in inflamatory bowel disease. Gut 2001;48(5):609.

Tasteyre, A., Barc, M. C., Karjalainen, T., Bourlioux, P., and Collignon, A. Inhibition of in vitro cell adherence of Clostridium difficile by Saccharomyces boulardii. Microb.Pathog. 2002;32(5):219-225.

Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801.

Cremonini, F., Di Caro, S., Santarelli, L., Gabrielli, M., Candelli, M., Nista, E. C., Lupascu, A., Gasbarrini, G., and Gasbarrini, A. Probiotics in antibiotic-associated diarrhoea. Dig.Liver Dis. 2002;34 Suppl 2:S78-S80.

Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41-43.

Mansour-Ghanaei, F., Dehbashi, N., Yazdanparast, K., and Shafaghi, A. Efficacy of saccharomyces boulardii with antibiotics in acute amoebiasis. World J Gastroenterol. 2003;9(8):1832-1833.

Gaon, D., Garcia, H., Winter, L., Rodriguez, N., Quintas, R., Gonzalez, S. N., and Oliver, G. Effect of Lactobacillus strains and Saccharomyces boulardii on persistent diarrhea in children. Medicina (B Aires) 2003;63(4):293-298.

Costalos, C., Skouteri, V., Gounaris, A., Sevastiadou, S., Triandafilidou, A., Ekonomidou, C., Kontaxaki, F., and Petrochilou, V. Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum.Dev. 2003;74(2):89-96.

Erdeve, O., Tiras, U., and Dallar, Y. The probiotic effect of Saccharomyces boulardii in a pediatric age group. J Trop.Pediatr. 2004;50(4):234-236.

Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224.

Kotowska, M., Albrecht, P., and Szajewska, H. Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial. Aliment.Pharmacol.Ther. 3-1-2005;21(5):583-590.

Kurugol, Z. and Koturoglu, G. Effects of Saccharomyces boulardii in children with acute diarrhoea. Acta Paediatr. 2005;94(1):44-47.

Surawicz, C. M. Treatment of recurrent Clostridium difficile-associated disease. Nat Clin Pract.Gastroenterol.Hepatol. 2004;1(1):32-38.

Duman, D. G., Bor, S., Ozutemiz, O., Sahin, T., Oguz, D., Istan, F., Vural, T., Sandkci, M., Isksal, F., Simsek, I., Soyturk, M., Arslan, S., Sivri, B., Soykan, I., Temizkan, A., Bessk, F., Kaymakoglu, S., and Kalayc, C. Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhoea due to Helicobacterpylori eradication. Eur J Gastroenterol.Hepatol. 2005;17(12):1357-1361.

Saint-Marc, T., Rossello-Prats, L., and Touraine, J. L. [Efficacy of Saccharomyces boulardii in the treatment of diarrhea in AIDS]. Ann Med Interne (Paris) 1991;142(1):64-65.

Kimmey, M. B., Elmer, G. W., Surawicz, C. M., and McFarland, L. V. Prevention of further recurrences of Clostridium difficile colitis with Saccharomyces boulardii. Dig.Dis Sci 1990;35(7):897-901.

Chapoy, P. [Treatment of acute infantile diarrhea: controlled trial of Saccharomyces boulardii]. Ann Pediatr.(Paris) 1985;32(6):561-563.

Tempe, J. D., Steidel, A. L., Blehaut, H., Hasselmann, M., Lutun, P., and Maurier, F. [Prevention of diarrhea administering Saccharomyces boulardii during continuous enteral feeding]. Sem.Hop. 5-5-1983;59(18):1409-1412.

Kollaritsch, H., Holst, H., Grobara, P., and Wiedermann, G. [Prevention of traveler's diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study]. Fortschr.Med 3-30-1993;111(9):152-156.

Born, P., Lersch, C., Zimmerhackl, B., and Classen, M. [The Saccharomyces boulardii therapy of HIV-associated diarrhea]. Dtsch Med Wochenschr 5-21-1993;118(20):765.

Kirchhelle, A., Fruhwein, N., and Toburen, D. [Treatment of persistent diarrhea with S. boulardii in returning travelers. Results of a prospective study]. Fortschr Med 4-20-1996;114(11):136-140.

Saint-Marc T, Rossello-Prats L, and Touraine JL. [Effectiveness of Saccharomyces boulardii in the management of AIDS diarrhea]. Ann Med Interne (Paris) 1991;142(1):64-65.

McFarland LV, SurawiczCM, Elmer GW, and et al. Multivariate analysis of the clinical efficacy of a biotherapeutic agent, Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea [abstract]. Am J Epidemiol 1993;138:649.

Adam J, Barret C, Barret-Bellet A, and et al. Essais cliniques controles en double insu de l'Ultra-Levure Lyophilisee. Etude multicentrique par 25 medecins de 388 cas. Gaz Med Fr 1977;84:2072-2078.

Cetina-Sauri G and Basto GS. Evaluacion terapeutica de Saccharomyces boulardii en ninos con diarrea aguda. Tribuna Med 1989;56:111-115.

Chouraqui JP, Dietsch J, Musial C, and et al. Saccharomyces boulardii (SB) in the management of toddler diarrhea: a double-blind-placebo controlled study [abstract]. J Pediatr Gastroenterol Nutr 1995;20(4):463.

McFarland LV, Surawicz C, Greenberg R, and et al. Saccharomyces boulardii and high dose vancomycin treats recurrent Clostridium difficile disease [abstract]. Am J Gastroenterol 1998;93(9):1694.

Saint-Marc T, Blehaut H, Musial C, and et al. [AIDS-related diarrhea: a double-blind trial of Saccharomyces boulardii]. Semaine Des Hopitaux 1995;71(23-24):735-741.

Maupas JL, Champemont P, and Delforge M. [Treatment of irritable bowel syndrome with Saccharomyces boulardii - a double-blind, placebo controlled study]. Médicine et Chirurgie Digestives 1983;12(1):77-79.

Bleichner G and Blehaut H. Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. A multicenter, randomized, double-blind placebo-controlled trial [abstract]. Clin Nutr 1994;13 Suppl 1:10.

Potts L, Lewis SJ, and Barry R. Randomised double blind placebo controlled study of the ability of Saccharomyces boulardii to prevent antibiotic related diarrhoea [abstract]. Gut 1996;38 (suppl 1):A61.

Elmer GW, Moyer KA, Vega R, and et al. Evaluation of Saccharomyces boulardii for patients with HIV-related chronic diarrhoea and in healthy volunteers receiving antifungals. Microecology Ther 1995;25:23-31.

Hempel S, Newberry SJ, Maher AR, Wang Z, Miles JN, Shanman R, Johnsen B, Shekelle PG. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA. 2012 9;307(18):1959-69.

Videlock EJ, Cremonini F. Meta-analysis: probiotics in antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2012;35(12):1355-69.

Serce O, Gursoy T, Ovali F, Karatekin G. Effects of Saccaromyces boulardii on neonatal hyperbilirubinemia: a randomized controlled trial. Am J Perinatol. 2015;30(2):137-142.

Bourreille A, et al. Saccharomyces boulardii does not prevent relapse of Crohn's disease. Clin Gastroenterol Hepatol. 2013;11(8):982-987.

Bafutto M, et al. Treatment of diarrhea-predominant irritable bowel syndrome with mesalamine and/or Saccharomyces boulardii. Arq Gastroenterol. 2013;50(4):304-309.

Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.

Szajewska H, Kolodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic -associated diarrhoea. Aliment Pharmacol Ther. 2015;42(7):793-801.

Szajewska H, Horvath A, Kolodziej M. Systematic review with meta-analysis: Saccharomyces boulardii supplementation and eradication of Helicobacter pylori infection. Aliment Pharmacol Ther. 2015;41(12):1237-1245.

Feizizadeh S, Salehi-Abargouei A, Akbari V. Efficacy and safety of Saccharomyces boulardii for acute diarrhea. Pediatrics. 2014;134(1):e176-191.

Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, Johnston BC. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015;(12):CD004827.

Das S, Gupta PK, Das RR. Efficacy and Safety of Saccharomyces boulardii in Acute Rotavirus Diarrhea: Double Blind Randomized Controlled Trial from a Developing Country. J Trop Pediatr. 2016;62(6):464-470.

Al Faleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2014;(4):CD005496.

Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients-A Systematic Review and Meta-Analysis. Antibiotics (Basel). 2017;6(4).

Chang HY, Chen JH, Chang JH, Lin HC, Lin CY, Peng CC. Multiple strains probiotics appear to be the most effective probiotics in the prevention of necrotizing enterocolitis and mortality: An updated meta-analysis. PLoS One. 2017;12(2):e0171579.

Appel-da-Silva MC, Narvaez GA, Perez LRR, Drehmer L, Lewgoy J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Med Mycol Case Rep. 2017;18:15-7.

Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35.

Choi CH, Jo SY, Park HJ, Chang SK, Byeon JS, Myung SJ. A randomized, double-blind, placebo-controlled multicenter trial of Saccharomyces boulardii in irritable bowel syndrome: effect on quality of life. J Clin Gastroenterol. 2011;45(8):679-83.

Martin IW, Tonner R, Trivedi J, et al. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017;87(3):286-8.

Pozzoni P, Riva A, Bellatorre AG, et al. Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea in adult hospitalized patients: a single-center, randomized, double-blind, placebo-controlled trial. Am J Gastroenterol 2012;107(6):922-31.

Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr 2017;35(3):361-4.

Roy U, Jessani LG, Rudramurthy SM, et al. Seven cases of Saccharomyces fungaemia related to use of probiotics. Mycoses 2017;60(6):375-380.

Lau CS, Chamberlain RS. Probiotics are effective at preventing Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Int J Gen Med. 2016;9:27-37.

Goldenberg JZ, Ma SS, Saxton JD, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2013;(5):CD006095.

Cohen SH, Gerding DN, Johnson S, et al.; Society for Healthcare Epidemiology of America; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010;31(5):431-55.

- Corrêa NB, Penna FJ, Lima FM, Nicoli JR, Filho LA. Treatment of acute diarrhea with Saccharomyces boulardii in infants. J Pediatr Gastroenterol Nutr 2011;53(5):497-501.

Riaz M, Alam S, Malik A, Ali SM. Efficacy and safety of Saccharomyces boulardii in acute childhood diarrhea: a double blind randomised controlled trial. Indian J Pediatr 2012;79(4):478-82.

Suganthi V, Das AG. Role of Saccharomyces boulardii in reduction of neonatal hyperbilirubinemia. J Clin Diagn Res 2016;10(11):SC12-SC15.

Remenova T, Morand O, Amato D, Chadha-Boreham H, Tsurutani S, Marquardt T. A double-blind, randomized, placebo-controlled trial studying the effects of Saccharomyces boulardii on the gastrointestinal tolerability, safety, and pharmacokinetics of miglustat. Orphanet J Rare Dis 2015;10:81.

Asmat S, Shaukat F, Asmat R, Bakhat HFSG, Asmat TM. Clinical Efficacy Comparison of Saccharomyces Boulardii and Lactic Acid as Probiotics in Acute Pediatric Diarrhea. J Coll Physicians Surg Pak. 2018;28(3):214-217.

Carstensen JW, Chehri M, Schønning K, et al. Use of prophylactic Saccharomyces boulardii to prevent Clostridium difficile infection in hospitalized patients: a controlled prospective intervention study. Eur J Clin Microbiol Infect Dis. 2018;37(8):1431-1439.

Costanza AC, Moscavitch SD, Faria Neto HC, Mesquita ET. Probiotic therapy with Saccharomyces boulardii for heart failure patients: a randomized, double-blind, placebo-controlled pilot trial. Int J Cardiol. 2015;179:348-50.

Cottrell J, Koenig K, Perfekt R, Hofmann R; Loperamide-Simethicone Acute Diarrhoea Study Team. Comparison of Two Forms of Loperamide-Simethicone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute Diarrhoea in Adults: A Randomised Non-Inferiority Clinical Trial. Drugs R D. 2015;15(4):363-73.

Dauby N. Risks of Saccharomyces boulardii-Containing Probiotics for the Prevention of Clostridium difficile Infection in the Elderly. Gastroenterology. 2017;153(5):1450-1451.

Dinleyici EC, Kara A, Dalgic N, et al. Saccharomyces boulardii CNCM I-745 reduces the duration of diarrhoea, length of emergency care and hospital stay in children with acute diarrhoea. Benef Microbes. 2015;6(4):415-21.

Ehrhardt S, Guo N, Hinz R, et al. Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea: A Randomized, Double-Masked, Placebo-Controlled Trial. Open Forum Infect Dis. 2016;3(1):ofw011.

Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4.

Ryan JJ, Hanes DA, Schafer MB, Mikolai J, Zwickey H. Effect of the Probiotic Saccharomyces boulardii on Cholesterol and Lipoprotein Particles in Hypercholesterolemic Adults: A Single-Arm, Open-Label Pilot Study. J Altern Complement Med. 2015;21(5):288-93.

Sheele J, Cartowski J, Dart A, et al. Saccharomyces boulardii and bismuth subsalicylate as low-cost interventions to reduce the duration and severity of cholera. Pathog Glob Health. 2015;109(6):275-82.

Xu L, Wang Y, Wang Y, et al. A double-blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I-745 in formula-fed preterm infants. J Pediatr (Rio J). 2016;92(3):296-301.

McDonald LC, Gerding DN, Johnson S, et al.; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society of Healthcare Epidemiology of America (SHEA). Clinical Infectious Diseases 2018;66(7):e1-e48.

García-Collinot G, Madrigal-Santillán EO, Martínez-Bencomo MA, et al. Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis.Dig Dis Sci. 2019.

Seddik H, Boutallaka H, Elkoti I, et al. Saccharomyces boulardii CNCM I-745 plus sequential therapy for Helicobacter pylori infections: a randomized, open-label trial. Eur J Clin Pharmacol. 2019;75(5):639-645.

Szajewska H, Kolodziej M, Zalewski BM. Systematic review with meta-analysis: Saccharomyces boulardii for treating acute gastroenteritis in children-a 2020 update. Aliment Pharmacol Ther. 2020.

Zhou BG, Chen LX, Li B, Wan LY, Ai YW. Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta-analysis with trial sequential analysis. Helicobacter. 2019;24(5):e12651.