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Black Cumin Seed

Source

The black cumin seed used at Mymmunity is the highest quality 10:1 potent extract

Botanical Details

Species‎: ‎N. sativa

Family‎: ‎Ranunculaceae

Genus‎: ‎Nigella

Immune support

Black seed is thought to have immunoprotectant effects. Preliminary evidence suggests it may help minimize chemotherapy-induced decreases in hemoglobin and leukocyte counts. It may also enhance the production of certain human interleukins and alter macrophages. Animal research suggests that black seed volatile oil affects counts and activity of neutrophils and other lymphocytes. It might also reduce the production of antibodies.

Other uses

Asthma. Research shows that taking black seed by mouth along with asthma medicines can improve coughing, wheezing, and lung function in some people with asthma. But it seems to work only in people with very low lung function before treatment. And it does not seem to work as well as the drugs theophylline or salbutamol.

Diabetes. Research shows that taking black seed can improve blood sugar levels in people with diabetes. But it doesn't seem to work as well as the diabetes drug metformin. Black seed might also improve levels of cholesterol in people with diabetes.

High blood pressure. Research shows that taking black seed by mouth might reduce blood pressure by a small amount.

Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility). Research shows that taking black seed oil increases the number of sperm and how quickly they move in men with infertility.

Breast pain (mastalgia). Research shows that applying a gel containing black seed oil to the breasts during the menstrual cycle reduces pain in women with breast pain.

How it works

There is some scientific evidence to suggest that black seed might help boost the immune system, fight cancer, prevent pregnancy, reduce swelling, and lessen allergic reactions by acting as an antihistamine, but there isn't enough information in humans yet.

Safety

When taken by mouth: When taken in small quantities, such as a flavoring for foods, black seed is LIKELY SAFE for most people. Black seed oil and black seed powder are POSSIBLY SAFE when the larger amounts found in medicine are used for 3 months or less. There isn't enough reliable information to know if the amounts found in medicine are safe when used for more than 3 months. Black seed can cause allergic rashes in some people. It can also cause stomach upset, vomiting, or constipation. It might increase the risk of seizures in some people.

When applied to the skin: Black seed oil or gel is POSSIBLY SAFE when applied to the skin, short-term. It can cause allergic rashes in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Black seed seems to be safe in food amounts during pregnancy. But taking the larger amounts found in medicine is LIKELY UNSAFE. Black seed can slow down or stop the uterus from contracting.

There isn't enough reliable information to know if black seed is safe to use when breast-feeding. Stay on the safe side and avoid use.

Children: Black seed oil is POSSIBLY SAFE for children when taken by mouth short-term and in recommended amounts.

Bleeding disorders: Black seed might slow blood clotting and increase the risk of bleeding. In theory, black seed might make bleeding disorders worse.

Diabetes: Black seed might lower blood sugar levels in some people. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use black seed.

Low blood pressure: Black seed might lower blood pressure. In theory, taking black seed might make blood pressure become too low in people with low blood pressure.

Surgery: Black seed might slow blood clotting, reduce blood sugar, and increase sleepiness in some people. In theory, black seed might increase the risk for bleeding and interfere with blood sugar control and anesthesia during and after surgical procedures. Stop using black seed at least two weeks before a scheduled surgery.


Interactions with medications

Cyclosporine (Neoral, Sandimmune)

Interaction Rating = Moderate Be cautious with this combination.

Talk to your health provider.

Black seed might decrease levels of cyclosporine in the blood. This has not been shown in humans. Theoretically, black seed might reduce how well cyclosporine is able to work.

Medications for diabetes (Antidiabetes drugs)

Interaction Rating = Moderate Be cautious with this combination.

Talk to your health provider.

Black seed might lower blood sugar in some people. Diabetes medications are also used to lower blood sugar. Taking black seed along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Medications for high blood pressure (Antihypertensive drugs)

Interaction Rating = Moderate Be cautious with this combination.

Talk to your health provider.

Black seed might decrease blood pressure in some people. Taking black seed along with medications used for lowering high blood pressure might cause your blood pressure to go too low. Do not take too much black seed if you are taking medications for high blood pressure.

Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.

Medications that decrease the immune system (Immunosuppressants)

Interaction Rating = Moderate Be cautious with this combination.

Talk to your health provider.

Black seed might increase the immune system. By increasing the immune system, black seed might decrease the effectiveness of medications that decrease the immune system.

Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating = Moderate Be cautious with this combination.

Talk to your health provider.

Black seed might slow blood clotting. Taking black seed along with medications that also slow blood clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Sedative medications (CNS depressants)

Interaction Rating = Moderate Be cautious with this combination.

Talk to your health provider.

Black seed might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Using black seed along with sedative medications might cause too much sleepiness.

Some sedative medications include Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Water pills (Diuretic drugs)

Interaction Rating = Moderate Be cautious with this combination.

Talk to your health provider.

Black seed increases the amount of urine made by the body. This might increase how much potassium and other minerals are lost by the body. "Water pills" can also decrease potassium in the body. Taking black seed along with "water pills" might decrease potassium in the body too much. Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others.

Interactions with Herbs, Supplements, and Foods

Herbs and supplements that might lower blood pressure

Black seed might lower blood pressure. Using it along with other herbs and supplements that have this same effect might increase the risk of blood pressure dropping too low in some people. Some of these products include andrographis, casein peptides, cat's claw, coenzyme Q-10, fish oil, L-arginine, lycium, stinging nettle, theanine, and others.

Herbs and supplements that might lower blood sugar

Black seed might lower blood sugar. Using it with other herbs and supplements that have this same effect might increase the risk of low blood sugar in some people. Some of these products include alpha-lipoic acid, devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, and Siberian ginseng.

Herbs and supplements that might slow blood clotting

Using black seed along with other herbs and supplements that can slow blood clotting might increase the risk of bleeding in some people. Some of these herbs and supplements include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, and others.

Herbs and supplements with sedative properties

Black seed might cause sleepiness or drowsiness. Using it along with other herbs and supplements that have the same effect might make you overly drowsy. Some of these herbs and supplements include 5-HTP, calamus, California poppy, catnip, hops, Jamaican dogwood, kava, St. John's wort, skullcap, valerian, yerba mansa, and others.

Iron

Black seed might increase the amount of iron in your blood. Taking black seed along with iron supplements might increase the effects and side effects of iron.

There are no known interactions with foods.

References

Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

Tyler VE. Herbs of Choice. Binghamton, NY: Pharmaceutical Products Press, 1994.

Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.

The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.

Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.

Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.

United States Pharmacopeial Convention, Inc., ed. Drug Information for the Health Care Professional. 19th ed. Englewood, CO: Micromedex Inc., 1999.

Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

Carlsen SM, Folling I, Grill V, et al. Metformin increases total homocysteine levels in non-diabetic male patients with coronary heart disease. Scand J Clin Lab Invest 1997;57:521-7.

Vorgerd M, Grehl T, Jager M, et al. Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial. Arch Neurol 2000;57:956-63.

Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.

Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.

Sun Y, Hersh EM, Talpaz M, et al. Immune restoration and/or augmentation of local graft versus host reaction by traditional Chinese medicinal herbs. Cancer 1983;52:70-3.

Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.

Zhang H, Huang J. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Chung Hsi I Chieh Ho Tsa Chih 1990;10:278-9, 260.

Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..

Carod-Artal FJ. [Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). Neurotoxic syndromes caused by the ingestion of plants, seeds and fruits]. Rev Neurol 2003;36:860-71.

Stegelmeier BL, James LF, Panter KE, et al. The pathogenesis and toxicokinetics of locoweed (Astragalus and Oxytropis spp.) poisoning in livestock. J Nat Toxins 1999;8:35-45.

Prieto JM, Recio MC, Giner RM, et al. Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. J Pharm Pharmacol 2003;55:1275-82.

Chu DT, Lepe-Zuniga J, Wong WL, et al. Fractionated extract of Astragalus membranaceus, a Chinese medicinal herb, potentiates LAK cell cytotoxicity generated by a low dose of recombinant interleukin-2. J Clin Lab Immunol 1988;26:183-7.

Hong CY, Ku J, Wu P. Astragalus membranaceus stimulates human sperm motility in vitro. Am J Chin Med 1992;20:289-94.

Hong CY, Lo YC, Tan FC, et al. Astragalus membranaceus and Polygonum multiflorum protect rat heart mitochondria against lipid peroxidation. Am J Chin Med 1994;22:63-70.

Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. I. Immune restoration of local xenogeneic graft-versus-host reaction in cancer patients by fractionated Astragalus membranaceus in vitro. J Clin Lab Immunol 1988;25:119-23.

Qun L, Luo Q, Zhang ZY, et al. Effects of astragalus on IL-2/IL-2R system in patients with maintained hemodialysis. Clin Nephrol 1999;52:333-4.

Shao BM, Xu W, Dai H, et al. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun 2004;320:1103-11.

McCulloch M, See C, Shu XJ, et al. Astragalus-based Chinese herbs and platinum-based chemotherapy for advanced non-small-cell lung cancer: meta-analysis of randomized trials. J Clin Oncol 2006;24:419-30.

Xu F, Zhang Y, Xiao S, et al. Absorption and metabolism of Astragali radix decoction: in silico, in vitro, and a case study in vivo. Drug Metab Dispos 2006;34:913-24.

Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.

Hou YD, Ma GL, Wu SH, et al. Effect of Radix Astragali seu Hedysari on the interferon system. Chin Med J (Engl) 1981;94:35-40.

Yang YZ, Jin PY, Guo Q, et al. Treatment of experimental Coxsackie B-3 viral myocarditis with Astragalus membranaceus in mice. Chin Med J (Engl) 1990;103:14-8.

Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.

Roberts AT, Martin CK, Liu Z, et al. The safety and efficacy of a dietary herbal supplement and gallic acid for weight loss. J Med Food. 2007;10:184-8.

Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. Curr.Diab.Rep. 2011;11(2):142-148.

Wang, H., Chang, B., and Wang, B. [The effect of herbal medicine including astragalus membranaceus (fisch) bge, codonpsis pilosula and glycyrrhiza uralensis fisch on airway responsiveness]. Zhonghua Jie.He.He.Hu Xi.Za Zhi. 1998;21(5):287-288.

Liu, J. P., McIntosh, H., and Lin, H. Chinese medicinal herbs for asymptomatic carriers of hepatitis B virus infection. Cochrane.Database.Syst Rev 2001;(2):CD002231.

Su, Y. C., Lin, C. J., Chen, K. T., Lee, S. M., Lin, J. S., Tsai, C. C., Chou, Y., and Lin, J. G. Effects of huangqi jianzhong tang on hematological and biochemical parameters in judo athletes. Acta Pharmacol.Sin. 2001;22(12):1154-1158.

Xia, D., Zeng, Y., and Liao, Z. [Clinical and experimental study of yushen jiangtang tablet in treating non-insulin dependent diabetes mellitus]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1999;19(2):90-92.

Zhou, S., Shao, W., and Zhang, W. [Clinical study of Astragalus injection plus ligustrazine in protecting myocardial ischemia reperfusion injury]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2000;20(7):504-507.

Chen, H. and Weng, L. [Comparison on efficacy in treating liver fibrosis of chronic hepatitis B between Astragalus Polygonum anti-fibrosis decoction and jinshuibao capsule]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2000;20(4):255-257.

Wang, F. Twenty-eight cases of diabetic foot ulcer and gangrene treated with the Chinese herbal medicine combined with injection of ahylsantinfarctase. J.Tradit.Chin Med. 2002;22(1):3-4.

Chen, K. T., Su, C. H., Hsin, L. H., Su, Y. C., Su, Y. P., and Lin, J. G. Reducing fatigue of athletes following oral administration of huangqi jianzhong tang. Acta Pharmacol.Sin. 2002;23(8):757-761.

McCulloch, M., Broffman, M., Gao, J., and Colford, J. M., Jr. Chinese herbal medicine and interferon in the treatment of chronic hepatitis B: a meta-analysis of randomized, controlled trials. Am J Public Health 2002;92(10):1619-1628.

Dai, C. F., Zhang, Z. Z., Qi, X. L., Zhang, M. X., and Li, Y. P. [Clinical and experimental study of treatment of nanmiqing capsule for chronic prostatitis]. Zhonghua Nan.Ke.Xue. 2002;8(5):379-382.

Zhou, J. Y., Fan, Y., Kong, J. L., Wu, D. Z., and Hu, Z. B. [Effects of components isolated from Astragalus membranaceus Bunge on cardiac function injured by myocardial ischemia reperfusion in rats]. Zhongguo Zhong.Yao Za Zhi. 2000;25(5):300-302.

Shi, F. S., Yang, Z. G., and Di, G. P. [Effect of Astragalus saponin on vascular endothelial cell and its function in burn patients]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2001;21(10):750-751.

Gao, X. P., Zhao, W. X., and Zhang, Z. L. [Effect of huangqi zengmian powder on interstitial response in patients with esophageal cancer at peri-operational period]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2001;21(3):171-173.

Yang, Y. Z., Chen, R. Z., and Zhang, J. N. [Observation on collaborative treatment of dilated cardiomyopathy]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2001;21(4):254-256.

Liu, Z. Q., Li, Q. Z., and Qin, G. J. [Effect of Astragalus injection on platelet function and plasma endothelin in patients with early stage diabetic nephropathy]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2001;21(4):274-276.

Niu, H. R., Lai, Z. H., and Yuan, L. [Observation on effect of supplementary treatment by Astragalus injection in treating senile pulmonary tuberculosis patients]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2001;21(5):349-350.

Tan, Y. W., Yin, Y. M., and Yu, X. J. [Influence of Salvia miltiorrhizae and Astragalus membranaceus on hemodynamics and liver fibrosis indexes in liver cirrhotic patients with portal hypertension]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2001;21(5):351-353.

Zhang, J. G., Gao, D. S., and Wei, G. H. [Clinical study on effect of Astragalus injection on left ventricular remodeling and left ventricular function in patients with acute myocardial infarction]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(5):346-348.

Wang, R. T., Shan, B. E., and Li, Q. X. [Extracorporeal experimental study on immuno-modulatory activity of Astragalus memhranaceus extract]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(6):453-456.

Duan, P. and Wang, Z. M. [Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(7):515-517.

Liu, Z. G., Xiong, Z. M., and Yu, X. Y. [Effect of astragalus injection on immune function in patients with congestive heart failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(5):351-353.

Wu, X. S., Chen, H. Y., and Li, M. [Clinical observation on effect of combined use of Astragalus and compound salviae injection in treating acute cerebral infarction]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(5):380-381.

Wei, H., Sun, R., Xiao, W., Feng, J., Zhen, C., Xu, X., and Tian, Z. Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients. Oncol.Rep. 2003;10(5):1507-1512.

Zhao, X. Z. [Effects of Astragalus membranaceus and Tripterygium hypoglancum on natural killer cell activity of peripheral blood mononuclear in systemic lupus erythematosus]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1992;12(11):669-71, 645.

Li, N. Q. [Clinical and experimental study on shen-qo injection with chemotherapy in the treatment of malignant tumor of digestive tract]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1992;12(10):579, 588-592.

Yao, X. J., Wainberg, M. A., and Parniak, M. A. Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris. Virology 1992;187(1):56-62.

Shon, Y. H. and Nam, K. S. Protective effect of Astragali radix extract on interleukin 1beta-induced in fl ammation in human amnion. Phytother.Res 2003;17(9):1016-1020.

Zhang, W. J., Hufnagl, P., Binder, B. R., and Wojta, J. Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression. Thromb.Haemost. 2003;90(5):904-914.

Zou, Y. H. and Liu, X. M. [Effect of astragalus injection combined with chemotherapy on quality of life in patients with advanced non-small cell lung cancer]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(10):733-735.

Huang, C. L. and Lu, Y. P. [Effect of Astragalus injection on insulin resistance in auxiliary treating patients with diabetes mellitus type 2]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(10):779-780.

Kim, C., Ha, H., Lee, J. H., Kim, J. S., Song, K., and Park, S. W. Herbal extract prevents bone loss in ovariectomized rats. Arch.Pharm.Res. 2003;26(11):917-924.

Li, Z. P., Cao, Q., and Xing, Q. S. [Effect of Milkvetch Injection on cardiac function and hemodynamics in children with tetralogy of Fallot after radical operation]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(12):891-894.

Sun, Y. and Yang, J. [Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type 1]. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2004;24(1):57-58.

Ma, K., Sun, L. H., and Wang, Q. H. [Clinical study on treatment of 405 cases of irregular menstruation by tiaojing zhixue granules]. Zhongguo Zhong.Yao Za Zhi. 2003;28(1):78-80.

Chen, M. L., Liu, W. J., Wang, C. Y., Zhu, X. M., Yin, J. F., Wang, D. X., and Liu, P. [Effects of yishenjiangyafang on blood pressure and protecting renal function in RPH rats]. Zhongguo Zhong.Yao Za Zhi. 2003;28(8):746-751.

Mao, S. P., Cheng, K. L., and Zhou, Y. F. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(2):121-123.

Xiao, H. B., Krucker, M., Albert, K., and Liang, X. M. Determination and identification of isoflavonoids in Radix astragali by matrix solid-phase dispersion extraction and high-performance liquid chromatography with photodiode array and mass spectrometric detection. J Chromatogr.A 4-2-2004;1032(1-2):117-124.

Liu, J., Liang, P., Yin, C., Wang, T., Li, H., Li, Y., and Ye, Z. Effects of several Chinese herbal aqueous extracts on human sperm motility in vitro. Andrologia 2004;36(2):78-83.

Liu, J. P., Yang, M., and Du, X. M. Herbal medicines for viral myocarditis. Cochrane.Database.Syst.Rev. 2004;(3):CD003711.

Wang, H. Y. and Chen, Y. P. [Clinical observation on treatment of diabetic nephropathy with compound fructus arctii mixture]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(7):589-592.

Gao, S. R., Bu, J. H., and Zhu, L. Z. [Preliminary exploration on effect of qilian decoction in intervention treatment of diabetes mellitus type 2 with insulin resistance and its influence on related inflammatory cytokines]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(7):593-595.

Liu, W. J., Liu, B., Guo, Q. L., Zhang, Y. C., Yuan, Y. J., Fu, X. D., Deng, Z. H., and Lin, J. [Influence of ganciclovir and astragalus membranaceus on proliferation of hematopoietic progenitor cells of cord blood after cytomegalovirus infection in vitro]. Zhonghua Er.Ke.Za Zhi. 2004;42(7):490-494.

Kusum, M., Klinbuayaem, V., Bunjob, M., and Sangkitporn, S. Preliminary efficacy and safety of oral suspension SH, combination of five chinese medicinal herbs, in people living with HIV/AIDS ; the phase I/II study. J.Med.Assoc.Thai. 2004;87(9):1065-1070.

Li, C., Cao, L., and Zeng, Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong.Univ Sci Technolog.Med Sci 2004;24(4):379-384.

Taixiang, W., Munro, A. J., and Guanjian, L. Chinese medical herbs for chemotherapy side effects in colorectal cancer patients. Cochrane.Database.Syst.Rev. 2005;(1):CD004540.

Kobayashi, H., Mizuno, N., Teramae, H., Kutsuna, H., Ueoku, S., Onoyama, J., Yamanaka, K., Fujita, N., and Ishii, M. Diet and Japanese herbal medicine for recalcitrant atopic dermatitis: efficacy and safety. Drugs Exp Clin Res. 2004;30(5-6):197-202.

Wu, Y., Ou-Yang, J. P., Wu, K., Wang, Y., Zhou, Y. F., and Wen, C. Y. Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B. Acta Pharmacol.Sin. 2005;26(3):345-352.

Lee, H. J. and Lee, J. H. Effects of medicinal herb tea on the smoking cessation and reducing smoking withdrawal symptoms. Am.J.Chin Med. 2005;33(1):127-138.

Chen, L., Xie, C., and Wu, L. Point injection of injectio radici astragali for treatment of post-chemotherapy adverse reactions. J Tradit.Chin Med 2005;25(1):21-22.

Zhang, J. G., Yang, N., and He, H. [Effect of astraglus injection on serum apoptosis relevant factors in patients with chronic heart failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;25(5):400-403.

Chen, L. P., Zhou, Q. L., and Yang, J. H. [Protective effects of astragali injection on tubular in patients with primary nephrotic syndrome]. Zhong.Nan.Da.Xue.Xue.Bao.Yi.Xue.Ban. 2004;29(2):152-153.

Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):187-190.

Ko, J. K., Lam, F. Y., and Cheung, A. P. Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis. World J Gastroenterol 10-7-2005;11(37):5787-5794.

Dong, J., Gu, H. L., Ma, C. T., Zhang, F., Chen, Z., and Zhang, Y. [Effects of large dose of Astragalus membranaceus on the dendritic cell induction of peripheral mononuclear cell and antigen presenting ability of dendritic cells in children with acute leukemia]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;25(10):872-875.

Shen, P., Liu, M. H., Ng, T. Y., Chan, Y. H., and Yong, E. L. Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro. J Nutr 2006;136(4):899-905.

Wu, J., Wang, Y. X., Su, W. L., Zhu, W. X., Lu, J. W., and Li, Z. K. Effect of astragalus injection on serious abdominal traumatic patients' cellular immunity. Chin J Integr.Med 2006;12(1):29-31.

Yan, H. J. [Clinical and experimental study of the effect of kang er xin-I on viral myocarditis]. Zhong Xi Yi Jie He Za Zhi 1991;11(8):468-70, 452.

Li, H. B., Ge, Y. K., Zhang, L., and Zheng, X. X. Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells. Life Sci 8-15-2006;79(12):1186-1193.

Wei, J. A., Sun, L. M., and Chen, Y. X. [Effects of Ailing Granule on immuno-reconstruction in HIV/AIDS patients]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2006;26(4):319-321.

Brush, J., Mendenhall, E., Guggenheim, A., Chan, T., Connelly, E., Soumyanath, A., Buresh, R., Barrett, R., and Zwickey, H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Phytother Res 2006;20(8):687-695.

Firenzuoli, F., Gori, L., Di Simone, L., and Morsuillo, M. Important bias in the Astragalus meta-analysis. J Clin Oncol 7-1-2006;24(19):3215-3216.

Li, S. M., Yan, J. X., and Yang, L. [Effects of Astragalus injection on renal tubular function in patients with IgA nephropathy]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2006;26(6):504-507.

Li, D. P., Chen, Q., and Yi, L. [Effects of yiqi huoxue method on cardiac function in patients with congestive heart failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2006;26(6):552-554.

Cai, X. Y., Xu, Y. L., and Lin, X. J. [Effects of radix Astragali injection on apoptosis of lymphocytes and immune function in patients with systemic lupus erythematosus]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2006;26(5):443-445.

Zhang, B. R., Li, S., Yuan, P. Y., Zhang, X. B., Cheng, L. X., Zhou, H. H., Zhou, C. Y., Liu, X. Y., Wang, X. L., Tian, G. Z., Lin, Q. G., and Sha, W. W. [Effects of injection of Huangqi injectio into Zusanli (ST 36) on immune function in the patient of schizophrenia]. Zhongguo Zhen.Jiu. 2006;26(9):625-628.

Yang, H. Y., Li, J., and Yi, M. [Study on chronical hepatitis B with treatment of integrative traditional Chinese and Western medicine]. Zhongguo Zhong.Yao Za Zhi. 2006;31(15):1277-1280.

Wang, G., Liu, C. T., Wang, Z. L., Yan, C. L., Luo, F. M., Wang, L., and Li, T. Q. Effects of Astragalus membranaceus in promoting T-helper cell type 1 polarization and interferon-gamma production by up-regulating T-bet expression in patients with asthma. Chin J Integr.Med 2006;12(4):262-267.

Su, L., Mao, J. C., and Gu, J. H. [Effect of intravenous drip infusion of cyclophosphamide with high-dose Astragalus injection in treating lupus nephritis]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2007;5(3):272-275.

Wang, M. S., Li, J., Di, H. X., Li, Z. L., Yang, S. L., Hou, W., Yan, J. Y., and Zhao, X. M. Clinical study on effect of Astragalus Injection and its immuno-regulation action in treating chronic aplastic anemia. Chin J Integr.Med 2007;13(2):98-102.

Cho, W. C. and Leung, K. N. In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. J Ethnopharmacol. 8-15-2007;113(1):132-141.

Wang, J. Y., Ma, G. W., Dai, S. Q., Rong, T. H., Wang, X., Lin, P., Ye, W. F., Zhang, L. J., Li, X. D., Zhang, X., and Yao, G. Y. [Effect of cellular immune supportive treatment on immunity of esophageal carcinoma patients after modern two-field lymph node dissection]. Ai.Zheng. 2007;26(7):778-781.

Shimizu, N., Tomoda, M., Kanari, M., and Gonda, R. An acidic polysaccharide having activity on the reticuloendothelial system from the root of Astragalus mongholicus. Chem.Pharm Bull.(Tokyo) 1991;39(11):2969-2972.

Ahmed, M. S., Hou, S. H., Battaglia, M. C., Picken, M. M., and Leehey, D. J. Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus. Am J Kidney Dis 2007;50(6):1028-1032.

Brunetti, L. and DeSantis, E. R. Treatment of viral myocarditis caused by coxsackievirus B. Am J Health Syst.Pharm. 1-15-2008;65(2):132-137.

Ai, P., Yong, G., Dingkun, G., Qiuyu, Z., Kaiyuan, Z., and Shanyan, L. Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide. J Ethnopharmacol. 3-28-2008;116(3):413-421.

Ye, M. N. and Chen, H. F. [Effects of Astragalus injection on proliferation of basal-like breast cancer cell line MDA-MB-468]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2008;6(4):399-404.

Pan, H. F., Fang, X. H., Li, W. X., Ye, D. Q., Wu, G. C., and Li, X. P. Radix Astragali: a promising new treatment option for systemic lupus erythematosus. Med Hypotheses 2008;71(2):311-312.

Qu, X. L., Dai, Q., Qi, Y. H., Tang, Y. H., Xu, D. H., Wu, Z. H., and Wang, X. X. [Effects of Astragalous Injection on oxidative stress status in maintenance hemodialysis patients]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2008;6(5):468-472.

Xu, G. H., Yuan, L., Li, Y., Xie, P., Zhao, J. Y., and Chen, Y. H. [Clinical observation of Astragalus Injection in treatment of renal injury in patients with primary hypertension]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2008;6(5):530-532.

Haines, C. J., Lam, P. M., Chung, T. K., Cheng, K. F., and Leung, P. C. A randomized, double-blind, placebo-controlled study of the effect of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) on menopausal symptoms in Hong Kong Chinese women. Climacteric. 2008;11(3):244-251.

Wang, F., Xiao, M. D., and Liao, B. [Effect of Astragalus on cytokines in patients undergoing heart valve replacement]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2008;28(6):495-498.

Yang, S. P., Dong, H., and Wu, Y. C. [Clinical effect of milkvetch extract oral liquid in preventing and treating children's recurrent respiratory tract infection]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2008;28(6):544-547.

Shi, H. M., Dai, R. H., and Wang, S. Y. [Primary research on the clinical significance of ventricular late potentials (VLPs), and the impact of mexiletine, lidocaine and Astragalus membranaceus on VLPs]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1991;11(5):265-7, 259.

Song, J. Y., Meng, L. Q., and Li, X. M. [Therapeutic application and prospect of Astragalus membranaceus and Angelica sinensis in treating renal microvascular lesions]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2008;28(9):859-861.

Auyeung, K. K., Law, P. C., and Ko, J. K. Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. Int.J Mol.Med 2009;23(2):189-196.

Lau, T. W., Chan, Y. W., Lau, C. P., Lau, K. M., Lau, C. B., Fung, K. P., Leung, P. C., and Ho, Y. Y. Radix Astragali and Radix Rehmanniae, the principal components of two antidiabetic foot ulcer herbal formulae, elicit viability-promoting effects on primary fibroblasts cultured from diabetic foot ulcer tissues. Phytother.Res 2009;23(6):809-815.

Chen, W., Li, Y. M., and Yu, M. H. Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation. J Diabetes Complications 2010;24(3):199-208.

Jiangbo, Z., Xuying, W., Yuping, Z., Xili, M., Yiwen, Z., and Tianbao, Z. Effect of astragaloside IV on the embryo-fetal development of Sprague-Dawley rats and New Zealand White rabbits. J Appl.Toxicol. 2009;29(5):381-385.

Cho, J. H., Cho, C. K., Shin, J. W., Son, J. Y., Kang, W., and Son, C. G. Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: a randomised, double-blind, controlled pilot study. Complement Ther.Med 2009;17(3):141-146.

Cassileth, B. R., Rizvi, N., Deng, G., Yeung, K. S., Vickers, A., Guillen, S., Woo, D., Coleton, M., and Kris, M. G. Safety and pharmacokinetic trial of docetaxel plus an Astragalus-based herbal formula for non-small cell lung cancer patients. Cancer Chemother.Pharmacol. 2009;65(1):67-71.

Zuo, C., Xie, X. S., Qiu, H. Y., Deng, Y., Zhu, D., and Fan, J. M. Astragalus mongholicus ameliorates renal fibrosis by modulating HGF and TGF-beta in rats with unilateral ureteral obstruction. J Zhejiang.Univ Sci B 2009;10(5):380-390.

Niu, G. H., Sun, X., and Zhang, C. M. [Effect of compound astragalus recipe on lymphocyte subset, immunoglobulin and complements in patients with myasthenia gravia]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2009;29(4):305-308.

Qu, Z. L., Dong, H., and Wang, S. D. [Effects of astragalus injection on renal function in patients after cardiac valve replacement with cardiopulmonary bypass]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2009;29(4):313-316.

Ko, J. K. and Chik, C. W. The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines. Cytokine 2009;47(2):85-90.

Gao, X. H., Xu, X. X., Pan, R., Li, Y., Luo, Y. B., Xia, Y. F., Murata, K., Matsuda, H., and Dai, Y. Saponin fraction from Astragalus membranaceus roots protects mice against polymicrobial sepsis induced by cecal ligation and puncture by inhibiting inflammation and upregulating protein C pathway. J Nat.Med 2009;63(4):421-429.

Song, J., Meng, L., Li, S., Qu, L., and Li, X. A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, improved renal microvascular insufficiency in 5/6 nephrectomized rats. Vascul.Pharmacol. 2009;50(5-6):185-193.

Wang, L., Zhang, M. Z., and Yang, G. Combined therapy with Chinese medicine and percutaneous transradial coronary intervention for a centenarian patient with acute myocardial infarction. Chin J Integr.Med 2009;15(3):233-235.

Wu, J. H., Li, Q., Wu, M. Y., Guo, D. J., Chen, H. L., Chen, S. L., Seto, S. W., Au, A. L., Poon, C. C., Leung, G. P., Lee, S. M., Kwan, Y. W., and Chan, S. W. Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways. J Nutr Biochem. 2010;21(7):613-620.

Aldarmaa, J., Liu, Z., Long, J., Mo, X., Ma, J., and Liu, J. Anti-convulsant effect and mechanism of Astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction. Neurochem.Res 2010;35(1):33-41.

Tang, L. L., Sheng, J. F., Xu, C. H., and Liu, K. Z. Clinical and experimental effectiveness of Astragali compound in the treatment of chronic viral hepatitis B. J Int Med Res 2009;37(3):662-667.

Liang, H. Y., Hou, F., Ding, Y. L., Zhang, W. N., Huang, X. H., Zhang, B. Y., and Liu, Y. [Clinical evaluation of the antioxidant activity of astragalus in women with gestational diabetes]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2009;29(7):1402-1404.

Yuan, Y., Sun, M., and Li, K. S. Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-alpha and interleukin-8. World J Gastroenterol. 8-7-2009;15(29):3676-3680.

Lee, T. M., Guo, L. G., Shi, H. Z., Li, Y. Z., Luo, Y. J., Sung, C. Y., Chan, C. C., and Lee, T. M. Neural correlates of traditional Chinese medicine induced advantageous risk-taking decision making. Brain Cogn 2009;71(3):354-361.

Motomura, K., Fujiwara, Y., Kiyota, N., Tsurushima, K., Takeya, M., Nohara, T., Nagai, R., and Ikeda, T. Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products. J Agric.Food Chem. 9-9-2009;57(17):7666-7672.

Huh, J. E., Kwon, N. H., Baek, Y. H., Lee, J. D., Choi, D. Y., Jingushi, S., Kim, K. I., and Park, D. S. Formononetin promotes early fracture healing through stimulating angiogenesis by up-regulating VEGFR-2/Flk-1 in a rat fracture model. Int Immunopharmacol. 2009;9(12):1357-1365.

Zhang, Z. X., Wu, L. L., and Chen, M. [Effect of lixu jieyu recipe in treating 75 patients with chronic fatigue syndrome]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2009;29(6):501-505.

Omura, Y., Henoch, A., Shimotsuura, Y., Duvvi, H., Kawashima, H., and Ohki, M. Severe asthma with markedly increased asbestos of 2 types & TXB2, and markedly reduced acetylcholine, DHEA & drug uptake in parts of upper lungs, & similar abnormalities at respiratory & cardiac center of medulla oblongata: complete elimination of this asthma within 15 days using one optimal dose of astragalus & application of strong red light & EMF neutralizer on respiratory centers of abnormal medulla oblongata. Acupunct.Electrother.Res 2009;34(1-2):41-73.

Ye, Z. B., Wang, F. J., Zhang, G. Q., Yang, W. M., Qin, H. S., and Liu, X. T. [Effects of Astragalus Membranaceus Injection on TNF-alpha-induced release of inflammatory factors from HUVECs and the molecular mechanisms]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2009;29(6):1137-1140.

Chen, C. J., Li, Z. L., Fu, Q., Liu, Y., Lei, X., Wu, H. C., and Liu, Y. F. [Effect of Astragalus polysaccharides on the phenotype and functions of human dendritic cells in vitro]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2009;29(6):1192-1194.

Chao, M., Zou, D., Zhang, Y., Chen, Y., Wang, M., Wu, H., Ning, G., and Wang, W. Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients. Endocrine. 2009;36(2):268-274.

Zhou, R. F., Liu, P. X., and Tan, M. [Effect of Astragalus mongholicus injection on proliferation and apoptosis of hormone sensitive (MCF-7) breast cancer cell lines with physiological dose E2]. Zhong.Yao Cai. 2009;32(5):744-747.

Liu, X., Yang, Y., Zhang, X., Xu, S., He, S., Huang, W., and Roberts, M. S. Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2 cell. J Gastroenterol.Hepatol. 2010;25(2):420-426.

Wong, E. L., Sung, R. Y., Leung, T. F., Wong, Y. O., Li, A. M., Cheung, K. L., Wong, C. K., Fok, T. F., and Leung, P. C. Randomized, double-blind, placebo-controlled trial of herbal therapy for children with asthma. J Altern.Complement Med 2009;15(10):1091-1097.

Zou, F., Mao, X. Q., Wang, N., Liu, J., and Ou-Yang, J. P. Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK. Acta Pharmacol.Sin. 2009;30(12):1607-1615.

Wojcikowski, K., Wohlmuth, H., Johnson, D. W., and Gobe, G. Effect of Astragalus membranaceus and Angelica sinensis combined with Enalapril in rats with obstructive uropathy. Phytother.Res 2010;24(6):875-884.

Wang, J., Zhang, Q. Y., and Chen, Y. X. [Effects of Astragalus membranaceus on cytokine secretion of peripheral dendritic cells in children with Henoch-Schonlein purpura in the acute phase]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2009;29(9):794-797.

Cui, X., Trinh, K., and Wang, Y. J. Chinese herbal medicine for chronic neck pain due to cervical degenerative disc disease. Cochrane.Database.Syst.Rev. 2010;(1):CD006556.

Huh, J. E., Seo, D. M., Baek, Y. H., Choi, D. Y., Park, D. S., and Lee, J. D. Biphasic positive effect of formononetin on metabolic activity of human normal and osteoarthritic subchondral osteoblasts. Int Immunopharmacol. 2010;10(4):500-507.

Lee, J. J. and Lee, J. J. A phase II study of an herbal decoction that includes Astragali radix for cancer-associated anorexia in patients with advanced cancer. Integr.Cancer Ther. 2010;9(1):24-31.

Leehey, D. J., Casini, T., and Massey, D. Remission of membranous nephropathy after therapy with Astragalus membranaceus. Am J Kidney Dis. 2010;55(4):772.

Zhang, Y., Liu, J., Wang, J., and He, Q. Traditional Chinese Medicine for treatment of cerebral palsy in children: a systematic review of randomized clinical trials. J Altern.Complement Med 2010;16(4):375-395.

Liu, Z. L., Liu, Z. J., Liu, J. P., Yang, M., and Kwong, J. Herbal medicines for viral myocarditis. Cochrane.Database.Syst.Rev. 2010;7:CD003711.

Liu, Q. Y., Yao, Y. M., Zhang, S. W., and Sheng, Z. Y. Astragalus polysaccharides regulate T cell-mediated immunity via CD11c(high)CD45RB(low) DCs in vitro. J Ethnopharmacol. 7-8-2010;

Wang, J. J., Li, J., Shi, L., Lv, X. W., Cheng, W. M., and Chen, Y. Y. Preventive effects of a fractioned polysaccharide from a traditional Chinese herbal medical formula (Yu Ping Feng San) on carbon tetrachloride-induced hepatic fibrosis. J Pharm.Pharmacol. 2010;62(7):935-942.

Fang, J. Y. [Effect of fu-zheng qu-xie on gastric disease infected with Campylobacter pyloridis]. Zhong Xi Yi Jie He Za Zhi 1991;11(3):150-2, 133.

Hoo, R. L., Wong, J. Y., Qiao, C., Xu, A., Xu, H., and Lam, K. S. The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. Nutr Metab (Lond) 2010;7:67.

Yang, Q. Y., Lu, S., and Sun, H. R. [Effects of astragalus on cardiac function and serum tumor neorosis factor-alpha level in patients with chronic heart failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2010;30(7):699-701.

Li, M., Wang, W., Xue, J., Gu, Y., and Lin, S. Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. J Ethnopharmacol. 1-27-2011;133(2):412-419.

Zhang, Z. H., Zhou, G., Gong, X., Zhang, R., Qu, X. G., Zeng, C., and Liu, J. L. [Effects of Hengyan medicinal recipe on the regulation of immunity in patients with severe sepsis: a prospective clinical trial]. Zhongguo Wei Zhong.Bing.Ji.Jiu.Yi.Xue. 2011;23(2):77-80.

Yang, Q. Y., Lu, S., and Sun, H. R. Clinical effect of Astragalus granule of different dosages on quality of life in patients with chronic heart failure. Chin J Integr Med 2011;17(2):146-149.

Zhao, K. S., Mancini, C., and Doria, G. Enhancement of the immune response in mice by Astragalus membranaceus extracts. Immunopharmacology 1990;20(3):225-233.

Fu, S., Zhang, J., Menniti-Ippolito, F., Gao, X., Galeotti, F., Massari, M., Hu, L., Zhang, B., Ferrelli, R., Fauci, A., Firenzuoli, F., Shang, H., Guerra, R., and Raschetti, R. Huangqi injection (a traditional Chinese patent medicine) for chronic heart failure: a systematic review. PLoS.One. 2011;6(5):e19604.

Xiong, M., He, Q., Lai, H., Huang, W., Wang, L., Yang, C., and Wang, J. Radix Astragali injection enhances recovery from acute acoustic trauma. Acta Otolaryngol. 2011;131(10):1069-1073.

Qian, Z. W., Mao, S. J., Cai, X. C., Zhang, X. L., Gao, F. X., Lu, M. F., Shao, X. S., Li, Y. Y., Yang, X. K., Zhuo, Y. A., and . Viral etiology of chronic cervicitis and its therapeutic response to a recombinant interferon. Chin Med J (Engl.) 1990;103(8):647-651.

Ti, Y. X., Pan, Z. X., and Wu, C. [Intervention of astragalus injection on the kidney injury after cardiopulmonary bypass of infants with congenital heart disease]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2011;31(5):631-634.

Xiong, M., He, Q., Lai, H., Huang, W., Wang, L., and Yang, C. Radix astragali injection enhances recovery from sudden deafness. Am J Otolaryngol. 2012;33(5):523-527.

Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest Med 2012;35(1):E1-11.

Wu, H. M., Tang, J. L., Cao, L., Sha, Z. H., and Li, Y. Interventions for preventing infection in nephrotic syndrome. Cochrane Database Syst.Rev. 2012;4:CD003964.

Zhang ZL, Wen QZ, and Liu CX. Hepatoprotective effects of astraglus root. Journal of Ethnopharmacology 1990;30(2):145-149.

Lu, Z. M., Qian, X. H., Chen, Z. W., Zhang, C. H., Guo, L. S., and Chen, J. [Prospective clinical study of radix astragali and its compound prescription for treatment of beta-thalassemia in children]. Zhongguo Dang.Dai Er.Ke.Za Zhi. 2012;14(5):344-349.

Zhang, L. F., Cheng, W. D., Gui, M. M., Li, X. Y., and Wei, D. F. [Comparative study of Radix Hedyseri as sulstitute for Radix Astragali of yupingfeng oral liquid on cellular immunity in immunosuppressed mice]. Zhong.Yao Cai. 2012;35(2):269-273.

Liu, Z. L., Liu, Z. J., Liu, J. P., and Kwong, J. S. Herbal medicines for viral myocarditis. Cochrane Database Syst.Rev. 2012;11:CD003711.

Chen, Z. [Clinical study of 96 cases with chronic hepatitis B treated with jiedu yanggan gao by a double-blind method]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1990;10(2):71-4, 67.

Geng, C. S. [Advances in immuno-pharmacological studies on Astragalus membranaceus]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1986;6(1):62-64.

Wu, B. Q. [Cerebral infarction in 141 cases treated by traditional Chinese medicine and Western medicine]. Zhong Xi Yi Jie He Za Zhi 1989;9(11):656-7, 644.

Liao, J. Z., Chen, J. J., Wu, Z. M., Guo, W. Q., Zhao, L. Y., Qin, L. M., Wang, S. R., and Zhao, Y. R. Clinical and experimental studies of coronary heart disease treated with yi-qi huo-xue injection. J Tradit.Chin Med 1989;9(3):193-198.

Liao, J. Z., Chai, Z. N., Li, W. S., Liu, X. F., Wang, S., Qin, L., and Guo, W. Q. Pharmacologic effects of codonopsis pilosula-astragalus injection in the treatment of CHD patients. J Tradit.Chin Med 1988;8(1):1-8.

Dong, D. C., Zhou, L. F., and Chen, J. X. [Changes in proteinuria, renal function and immunity after treatment with injections of a solution of Astragalus membranaceus]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1987;7(7):403-4, 388.

He, Z. P., Wang, D. Z., Shi, L. Y., and Wang, Z. Q. Treating amenorrhea in vital energy-deficient patients with angelica sinensis-astragalus membranaceus menstruation-regulating decoction. J Tradit.Chin Med 1986;6(3):187-190.

Chen, L. X., Liao, J. Z., and Guo, W. Q. [Effects of Astragalus membranaceus on left ventricular function and oxygen free radical in acute myocardial infarction patients and mechanism of its cardiotonic action]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(3):141-143.

Peng, T. Q., Yang, Y. Z., and Kandolf, R. [Effect and mechanism of Astragalus membranaceus on coxsackie B3 virus RNA in mice]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1994;14(11):664-666.

Shi, H. M., Dai, R. H., and Fan, W. H. [Intervention of lidocaine and Astragalus membranaceus on ventricular late potentials]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Integrated Traditional and Western Medicine) 1994;14(10):598-600.

Li, S. Q., Yuan, R. X., and Gao, H. [Clinical observation on the treatment of ischemic heart disease with Astragalus membranaceus]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(2):77-80.

Cha, R. J., Zeng, D. W., and Chang, Q. S. [Non-surgical treatment of small cell lung cancer with chemo-radio- immunotherapy and traditional Chinese medicine]. Zhonghua Nei Ke.Za Zhi 1994;33(7):462-466.

Jin, R., Wan, L. L., Mitsuishi, T., Kodama, K., and Kurashige, S. [Immunomodulative effects of Chinese herbs in mice treated with anti- tumor agent cyclophosphamide]. Yakugaku Zasshi 1994;114(7):533-538.

Lu, D. C., Su, Z. J., and Rui, T. [Effect of jian yan ling on serum lipids, apoprotein and lipoprotein-a]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1994;14(3):142-144, 131-2.

Lei, Z. Y., Qin, H., and Liao, J. Z. [Action of Astragalus membranaceus on left ventricular function of angina pectoris]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1994;14(4):199-202.

Sheng, Z. L., Li, N. Y., and Ge, X. P. [Clinical study of baoyuan dahuang decoction in the treatment of chronic renal failure]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1994;14(5):268-70, 259.

Zhao, K. W. and Kong, H. Y. [Effect of Astragalan on secretion of tumor necrosis factors in human peripheral blood mononuclear cells]. Zhongguo Zhong Xi.Yi.Jie.He.Za Zhi. 1993;13(5):263-5, 259.

Su, Z. Z., He, Y. Y., and Chen, G. [Clinical and experimental study on effects of man-shen-ling oral liquid in the treatment of 100 cases of chronic nephritis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(5):269-60.

Zhang, B. Z., Ding, F., and Tan, L. W. [Clinical and experimental study on yi-gan-ning granule in treating chronic hepatitis B]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(10):597-9, 580.

Weng, X. S. [Treatment of leucopenia with pure Astragalus preparation--an analysis of 115 leucopenic cases]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(8):462-464.

Guo, Q., Peng, T. Q., and Yang, Y. Z. [Effect of Astragalus membranaceus on Ca2+ influx and coxsackie virus B3 RNA replication in cultured neonatal rat heart cells]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(8):483-485.

Burack, J. H., Cohen, M. R., Hahn, J. A., and Abrams, D. I. Pilot randomized controlled trial of Chinese herbal treatment for HIV- associated symptoms. J Acquir.Immune.Defic.Syndr.Hum.Retrovirol. 8-1-1996;12(4):386-393.

Luo, H. M., Dai, R. H., and Li, Y. [Nuclear cardiology study on effective ingredients of Astragalus membranaceus in treating heart failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(12):707-709.

Kajimura, K., Takagi, Y., Ueba, N., Yamasaki, K., Sakagami, Y., Yokoyama, H., and Yoneda, K. Protective effect of astragali radix by oral administration against Japanese encephalitis virus infection in mice. Biol.Pharm.Bull. 1996;19(9):1166-1169.

Batey RG, Bensoussan A, Fan YY, and et al. Preliminary report of a randomized, double-blind placebo-controlled trial of a Chinese herbal medicine preparation CH-100 in the treatment of chronic hepatitis C. Journal of Gastroenterology and Hepatology 1998;13(3):244-247.

Gu, W., Yang, Y. Z., and He, M. X. [A study on combination therapy of Western and traditional Chinese medicine of acute viral myocarditis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1996;16(12):713-716.

Lu, L. J., Zhao, D. Y., Li, S. Y., and Lin, Q. F. Clinical analysis of 179 cases of hepatitis B treated with Chinese herbal combination hepatitis B formula #3 [in Chinese]. Shandong J TCM 1992;11(2):15-17.

Wang, X. G., Tang, H. F., Liu, X. C., and Ren, H. K. Clinical observations of

Peng, M. H., Wang, X. Y., Sun, F. Y., Du, X. Z., Xiang, D. P., and Wang, W. S. [Observation of therapeutic effect of Astragalus membranaceus by acupoint injection for treatment of hepatitis B virus carriers]. Chinese Journal of Chinese Medicine and Pharmacology Information 1997;4(4):22-23.

Kang GG. Preventive effects of Huangqi on secondary infection in children with simple nephrotic syndrome. Chinese Journal of Integrated Traditional and Western Nephrology 2005;6(12):718-719.

Wang, H. Report of Clinical Trial of Compound Qishe Tablet: Phase II. 2004;

Wang, H. Report of Clinical Trial of Compount Qishe Tablet: Phase III. 2005;

Li, Q., Li, F., and Lu, J. Extractum Nucis Vomicae for the Peripheral Nerve Pressure Symptoms of Cervical Spondylopathy: a Randomized Control Observation of 306 Cases. Chinese Journal of Tissue Engineering Research and Clinical Rehabilitation 2007;11(23):4531-4533.

Zhou, Z. H. Effect of Huangqi injection in reducing microalbuminuria for patients with type 2 Diabetes. Journal of Medical Theory and Practice 2002;15:510-511.

Hu XF. Huanqi the treatment of viral myocarditis caused by the clinical research of arrhythmia. Full paper database of Chinese excellent dissertations by doctors and masters 2009;

Dong XP. Study on the effects of combined treatment with Radix Astragali injection for infantile viral myocarditis. Chinese Journal of Hospital Pharmacy 2011;31(1):64-65.

Chen, H. 104 cases of acute viral myocarditis treated with Astragalus membranaceus injection. Chinese Journal of Information on Traditional Chinese Medicine 1999;6(4):49.

Zeng, C. F. Clinical observation on 25 cases of acute viral myocarditis treated with combined method of Chinese and western medicine. Journal of Gansu College of Traditional Chinese Medicine 1997;14(3):28-30.

Park JH, Kim BK, Park MK, and et al. Anti-diabetic activity of herbal drugs. Kor J Pharmacogn 1997;28(2):72-74.

Shibata T, Sakai E, Nishi K, and Asetai M. Growth and glycoside content of Astragalus membranaceus (Bunge Leguminaceae) cultivated in different soil groups. Natural Medicine 1996;50:296-299.

Zhou, Y, Huang, Z, Huang, T, and et al. Clinical study of Shengxue Mixture in treating aplastic anemia. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(3):186-189.

Yang Y, Jin P, Guo Q, and et al. Effect of Astragulas membranaceus on natural killer cell activity and induction of alpha- and gamma- interferon in patients with coxsackie B viral myocarditis. Chinese Medical Journal 1990;103(4):304-307.

Yong WU, Yand OU, Ping J, Ke WU, and et al. Hypoglycemic effect of astragalus polysaccharide and its effect on PTP1B. Acta Pharmacol.Sin. 2005;26(2):345-352.

Yin X, Zhang S, Kong Y, and et al. Observation on efficiency of jiangtang capsule in treating diabetes mellitus type 2 with hyperlipidemia. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(3):214-216.

Tianqing P, Yingzhen Y, Riesemann H, and et al. The inhibitory effect of Astragalus membranaceus on coxsackie B-3 virus RNA replication. Chinese Medical Sciences Journal 1995;10(3):146-150.

Wei, L., Su, Z. J., and Guan, F. S. Randomized double-blind controlled study of therapeutic effects of Astragalus injection on children with cerebral palsy. Appl J Gen Pract 2008;3:234-235.

Sun Y, Chang Y, and Yu G. Effect of Fu-Zheng therapy in the management of malignant diseases. Chin Med J 1981;61:97-101.

Zhang HE and et al. Treatment of adult diabetes with Jiangtangjia tablet. Journal of Traditional Chinese Medicine 1986;27(4):37-39.

Bai R, Li Q Fang X. Therapeutic effect observation of Astragalus injection for the treatment of 25 cases of pulmonary heart failure. Journal of Shanxi Medical College of Continuing Education 1999;9(1):39-40.

Bao X. Astragalus injection for aged people with congestive heart failure. Pharmacology and Clinics of Chinese Materia Medica 1999;15(6):39-40.

Bu Q, Li S. The curative effect of Astragalus injection for aged patients with congestive heart failure. Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease 2005;3(11):1006.

Cai Q, Ma H Zhou J. Analysis the improvement of cardiac function of Astragalus injection for chronic congestive heart failure. Shanxi Medical Journal 2005;34(7):860-861.

Chu G, Peng X. Astragalus injection as assisted treatment for refractory heart failure. Hubei Journal of Traditional Chinese Medicine 2000;22(10):29.

Fan L. Observation of Chinese and Western medicine for the treatment of 72 cases with congestive heart failure. Journal of Practical Traditional Chinese Medicine 2004;20(9):501.

Fang Z, Qin Y. Clinical observation of Huangqi injection for congestive heart failure. Central Plains Medical Journal 2003;30(14):6-7.

Fu X. Clinical experience in Astragalus injection for congestive heart failure. Journal of Chinese Practical Medicine 2000;2(9):72.

Gao Z, Zhang L Xu Y Liu L Zhang L. Clinical observation of Astragalus injection for congestive heart failure. Hebei Medicine 1999;5(5):7-9.

Gao J. Clinical observation of Huangqi Injection for congestive heart failure. Journal of Guangdong College of Pharmacy 2005;21(5):610-611.

Gu X, Shang S Guo R. Astragalus injection as adjuvant therapy for 68 cases with congestive heart failure. Herald of Medicine 2003;22(8):556-557.

Guo H, Liu L Yuan W Miao Z. Therapeutic effect observation of Huangqi injection for the treatment of chronic pulmonary heart disease with heart failure. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine 2005;5(4):22.

Guo H, Chen H. Astragalus injection for 42 cases with chronic congestive heart failure. Central Plain Medical Journal 2006;33(2):85-86.

Hu J, Gan J. Astragalus injection for 30 cases with chronic heart failure. Chin J Clin Pharmacol Ther 2001;6(1):78.

Hu S. Therapeutic effect observation of Huangqi injection as assisted treatment for chronic heart failure. Medicine Innovation Research 2008;5(2):102-103.

Jiao X, Duan Y. Clinical research of Huangqi Injection on left ventricular remodeling in congestive heart failure. Journal of Shanxi College of Traditional Chinese Medicine 2006;29(3):19-20.

Li S, Lv M. Astragalus injection as the assisted treatment for 30 cases with pulmonary heart failure. Journal of Anhui TCM College 1997;16(2):19-20.

Li C, Zhu X. Therapeutic effect observation of Astragalus injection as assisted treatment for chronic congestive heart failure. J Med Theor & Prac 2002;15(11):1277-1278.

Li W, Zhao W. Clinical observation of Astragalus injection for 50 cases with chronic congestive heart failure. The Seventh National Chinese and Western Medicine Academic and Working Communication Conference of Rural Foot Layer 2002;35-37.

Li S, Hao J Wu F et al. Clinical therapeutic effect observation of different doses of Huangqi injection for congestive heart failure. Chinese Journal of the Practical Chinese with Modem Medicine 2003;3(16):1665-1667.

Li H, Xu J. The curative effect of the treatment of chronic congestive cardiac deficiency by Astragalue injection and digoxin. Sichuan Journal of Physiological Sciences 2006;28(2):81.

Li J, Xu B Xue J Chen L Ling W. Clinical observation on the effect of sodium nitroprusside combined with milkvetch root injection on chronic congestive heart failure. China Tropical Medicine 2007;7(8):1343-1344.

Liu Y, Wang H. Curative effect observation of traditional Chinese and western medicine for the treatment of congestive heart failure. Tianjin Journal of Traditional Chinese Medicine 2001;18(5):8.

Liu C, Li Y. Clinical observation of Huangqi injection for congestive heart failure. Journal of Liaoning College of TCM 2004;6(5):390.

Liu Y, Li Y. Clinical research on Huangqi injection for congestive heart failure. Journal of Practical Traditional Chinese Medicine 2005;21(4):198-199.

Liu Y. Effect of astragalus injection on heart failure in senile patients. Journal of Xinxiang Medical College 2005;22(3):244-245.

Liu A. Clinical observation of Huangqi injection for chronic congestive heart failure. Zhejiang JLTCWM 2005;15(1):32.

Liu Z. Effect of Huangqi injection on cardiac output of chronic heart failure. Journal of Chinese Modern Medicine 2006;3:5.

Lu Q. The treatment of 80 cases of intractable heart failure with traditional Chinese and Western medicine. Modern Journal of Integrated Traditional Chinese and Western Medicine 2000;9(1):61.

Lu Z, Zhao D Liu Y. Clinical observation of Astragalus injection for coronary heart failure. Public Medical Forum Magazine 2006;10(1):1-2.

Luo X. Clinical observation of Astragalus injection for 30 cases with congestive heart failure. Journal of Emergency in Traditional Chinese Medicine 2003;12(1):35.

Luo Q, Wang Y Hu M. Therapeutic effect observation of Astragalus injection with conventional therapy for 46 elderly patients with chronic congestive heart failure. Heilongjiang Journal of Traditional Chinese Medicine 2004;3:8-9.

Lv J. Observation of western medicine combined with Huangqi injection for 36 patients with chronic heart failure. Journal of Practical Traditional Chinese Medicine 2008;24(3):164-165.

Ma Z, Cheng X Wang L. Huangqi injection as the assisted treatment for 86 cases with chronic pulmonary heart failure. Shanxi Journal of Traditional Chinese Medicine 2001;22(10):579-580.

Ma L, Yu J Han Y. Clinical observation of Huangqi injection for the treatment of pulmonary heart disease refractory heart failure. Henan Traditional Chinese Medicine 2005;25(10):78.

Pang M, Guo F Sun X Guo L. Effective observation of Astragalus injection for refractory heart failure. China Pharmaceuticals 2000;9(7):44.

Qin L. Therapeutic effect observation of Chinese and western medicine in the treatment of congestive heart failure. Journal of Shaanxi College of Traditional Chinese Medicine 2000;23(4):46-47.

Su X, Liu C. Clinical observation of injection Huangqi treating 46 patients with heart failure. Journal of Heze Medical College 2002;14(3):21.

Tian L, Ai J Deng C. Clinical observation of Huangqi injection combined with captopril for the treatment of 46 cases with chronic pulmonary heart failure. Shanghai Medical & Pharmaceutical Journal 1997;11:16.

Tian L, Ai J Wu X. Huangqi injection combined with dobutamine for the treatment of 54 patients with chronic pulmonary heart disease refractory heart failure. Modern Journal of Integrated Traditional Chinese and Western Medicine 2005;14(5):610.

Wang L. The observation of Astragalus injection combined with Nitroglycerin for heart failure. Chongqing Medical Journal 2000;29(1):71-72.

Wang S, Yu L. Clinical observation of astragalus in treatment of heart failure in 102 cases with chronic pulmonary heart disease. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2002;9(4):230-231.

Wang H. Clinical research on Astragalus injection as assisted treatment for refractory heart failure. Journal of Emergency in Traditional Chinese Medicine 2005;14(11):1070-1071.

Wei Y, Li C Chen X Liu Y Luo N. Effect of Astragalus parenteral solution of cytokines and angiotensin II in patients with congestive heart failure. Chinese Journal of Clinical Rehabilitation 2006;10(3):54-56.

Wu C. Clinical effects of Huangqi injection on heart failure. Guilin Medicine 2001;3:19-20.

Wu L. Therapeutic effect observation of Huangqi injection for the treatment of chronic pulmonary heart failure. Xinjiang Medical Journal 2004;34:107-108.

Xi Z, Jin X. Therapeutic effect observation of Astragalus injection for congestive heart failure. Modern Medicine & Health 2005;21(17):2337-2338.

Yang L, Zhang Y Yang G et al. The therapeutic effect of Astragalus injection on chronic heart failure. Shanghai Medical & Pharmaceutical Journal 1996;2:17-18.

Yang Z, Liu M. Effect of Huangqi injection on incidence of digitalism during the treatment of congestive heart failure. Traditional Chinese Drug Research & Clinical Pharmacology 1998;9(2):80-81.

Yang J, Xie Q. Therapeutic effect observation of Huangqi injection for chronic heart failure. Modern Journal of Integrated Traditional Chinese and Western Medicine 2000;9(12):1331.

Yang H, Kang X. Effects of Astragalus membranaceus on plasma BNP and NT-BNP during chronic heart failure. Chinese Health Care 2005;13(18):9-10.

Yang Y. Therapeutic effect observation of Astragalus injection combined with Western medicine for congestive heart failure. World Health Digest 2007;4(11):31-32.

Yin J, Wei Q. Therapeutic effect of Astragalus membranaceus injection on heart failure caused by pulmonary heart disease. Hebei Journal TCM 2002;24(4):308-309.

Zeng J. The clinical observation of Astragalus injection for congestive heart failure. Academic Proceedings of National Emergency Medicine Conference on Serious Disease 2005;156-157.

Zhai L, Wang M Yue J Ma Y. Clinical observation of Huangqi Injection for congestive heart failure. Shanghai Medical & Pharmaceutical Journal 1995;11:11-12.

Zhang L, Wang G Zhang G. Therapeutic effect observation of Huangqi injection as assisted treatment for pulmonary heart failure. Tibetan Medical Journal 2000;21(2):14-15.

Zhang D. Therapeutic effect observation of Astragalus injection for the treatment of 42 cases of pulmonary heart failure. Modern Journal of Integrated Traditional Chinese and Western Medicine 2002;11(5):408.

Zhang J, Jia L Du Y. Effects of Astragalus on cardiac function and hemorrheology in aged patients with congestive heart failure. Practical Geriatrics 2003;17(4):192-194.

Zhao Z, Liu F Yang L. Huangqi injection as the assisted treatment for congestive heart failure. The Practical Journal of Integrating Chinese with Modern Medicine 1998;11(1):26.

Zhou Z, Cai A Luo C Zeng X. Clinical observation of Astragalus injection as adjuvant therapy for coronary heart failure. Hubei Journal of Traditional Chinese Medicine 2002;24(9):11-12.

Xiangzhe J. A clinical investigation on 30 cases of senile benign renal arteriosclerosis treated bu Huang qi gu jing yin. Journal of Traditional Chinese Medicine 2001;21(3):177-180.

Dai, F. and Long, Y. C. Combined Chinese and Western treatment of chronic hepatitis B: an analysis of 38 cases [in Chinese]. J Anhui University TCM 1998;17(3):18-19.

Fu, Q. P. Chinese herbal medicine and interferon in the treatment of hepatitis B and D [in Chinese]. Harbin Med 1997;17(3):50-52.

Song, T. W. and Song, Y. Z. Treatment of asymptomatic hepatitis B carriers by TCM spleen/kidney theory: an analysis of 80 cases [in Chinese]. Zhejiang J TCM 1994;29:487-488.

Wang, M. S. Clinical survey of 64 cases of chronic hepatitis B treated with yellow dragon tea [in Chinese]. Chin J Indigenous Med 1997;3(3):21-22.

Zhao, X. W. and Guo, C. Q. Kang qian wei in the treatment of chronic hepatitis B [in Chinese]. Hunan Bull TCM 1996;2(2):7-10.

Chen J, Chen SQ. Preventive effects of Huangqi on infection in children with nephrotic syndrome. Zhong Guo Zhong Xi Yi Jie He Za Zhi [Chinese Journal of Integrated Traditional and Western Medicine] 2008;28(5):467-469.

Mo, W., Shi, Q., Hou, B., Ge, J., Ye, J., and Wan, H. Effect of Traditional Chinese Medicine Therapy with Single Disease Control in the Treatment of Mild Cervical Spondylotic Myelopathy. Chinese Journal of Clinical Rehabilitation 2005;9(46):102-104.

Wang, Y. G. An X. J. Wu X. Z. Application of Astragalus injection on diabetic nephropathy complicated with chronic renal failure. Journal of Practical Emergency Medicine Integrated Chinese and Western Medicine 1999;6:230-231.

Zhang, H. Shi X. Ji J. L. The effect of Astragalus injection on proteinuria in diabetic nephropathy. Henan Journal of Chinese Medicine 2001;16:36-37.

Wang, G. L. Wei X. P. Observation of recent curative effect of Astragalus membranaceus injection on diagetic nephropathy. Chinese Journal of Primary Medicine and Pharmacy 2003;10:38-39.

Shi, P. Li Z. Reducing micro-albuminuria of Huangci in diabetic nephropathy. Journal of Modern Clinical Medicine 2005;31:89-90.

Zeng, F. The effect of Astragalus injection on incipient diabetic nephropathy and plasma endothelin. Jiangxi Journal of Traditional Chinese Medicine 2005;36:26-27.

Ji, L. Pan M. P. Wang L. Efficacy of Astragalus injection for diabetic nephropathy. Practical Journal of Medicine and Pharmacology 2006;23:439-440.

Yang, R. F. Application of Astragalus injection on 56 patients with diabetic nephropathy. Medical Tribune 2006;27:84-85.

Miao, Q. F. Wang L. Wang J. Y. The effect of Astragalus on diabetic nephropathy. Journal of Bethune Medical University 2000;26:146-1146.

Xu, Y. F. Efficacy of Astragalus for postponing the deterioration of renal function in patients with diabetic nephropathy. Fujian Medical Journal 2002;24:101-102.

Cui, B. Yao M. Y. Tao Y. F. The effect of Astragalus on diabetic nephropathy stage V. Hainan Medicine 2005;16:58-59.

Su, F. Clinical observation of the effect of Astragalus injection on diabetic nephropathy. Ningxia Medical Journal 2006;28:220-221.

Bi, Z. J. Application of Astragalus injection on 68 patients with diabetic nephropathy. Chinese Journal of Integrative Medicine on Cardio-Cerebro Vascular Disease 2008;6:114-115.

Du, W. T. Li F. M. The effect of Astragalus on improvement of renal injury in early stage of diabetic nephropathy. Lishizhen Medicine and Materia Medica Research 2007;18:1743-1744.

Li, L. Diabetic nephropathy treating with Astragalus. Chinese Journal of Practice Medicine 2008;3:103-104.

Xie, B. X. Treatment of Astragalus membranaceus in 86 early diabetic nephrosis patients. Journal of Zhenjiang Medical College 2001;11:168-169.

Zhang, T. Gu H. D. Han J. H. Application of Astragalus injection on 31 patients with diabetic nephropathy. Chinese Journal of Emergency Medicine Integrated Chinese and Western Medicine 2001;8:283-1283.

Guo, Q. Y. Tang C. F. Fang X. H. Observation of the therapeutic effect of Astragalus injection on early stage of diabetic nephropathy. Chinese Journal of Rural Medicine 2004;11:11-12.

Liu, D. Liu S. Ding H. Investigation of the effect of Astragalus injection on treating diabetic nephropathy. Chinese Medicine of Factory and Mine 2004;17:446-447.

Wang, Q. L. Application of Astragalus injection on 30 patients with diabetic nephropathy. Central Plains Medical Journal 2004;31:6-7.

Ying, L. H. Observation of the therapeutic effect of Astragalus injection on diabetic nephropathy. Modern Journal of Integrated Traditional Chinese and Western Medicine 2005;14:988-989.

Zhang, L. Wang Y. J. Wang G. Z. Application of Astragalus injection with western medicine on proteinuria in patients with diabetic nephropathy. Shanxi Journal of Chinese Traditional Medicine 2005;26:1285-1286.

Zhang, X. F. Gao H. Y. The effect of Astragalus on early stage of diabetic nephropathy. Shanghai Medicine 1999;20:20-21.

Cheng, Z. R. Fang B. Q. Cheng Z. F. Song J. Z. Observation of treatment of early stage of diabetic nephropathy with Astragalus injection. Liaoning Journal of Practical Diabetes 2002;10:34-35.

Tan, Y. B. Clinical observation on the effect of Astragalactoside injection in the treatment of infantile viral myocarditis [in Chinese]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2003;10(1):60-1.

Zheng, R. 120 cases of viral myocarditis treated with integrated Chinese and western medicine [in Chinese]. The Journal of Medical Theory and Practice 2003;16(8):907-908.

Zhang, Z. Z., Yu, X. H., Zhang, P., and Yang, Y. H. Observation on 20 cases of viral myocarditis treated with

Zhou Y, Yu, X. H., and Yang, Y. H. Observation of astragaloside on treating viral myocarditis in 40 cases [in Chinese]. Chinese Journal of the Practical with Modern Medicine 2006;19(8):880-881.

Yang, Y. X. Clinical research on treatment of acute viral myocarditis by Astragalactoside injection [in Chinese]. World Health Digest Medical Periodical 2008;5(9):35.

Wu, J. W., Tao, N., Jiang, R. F., and Feng, H. D. Clinical observation on infantile viral myocarditis treated with radix astragali granules [in Chinese]. Journal of Pediatric Pharmacy 2009;15(1):23-5.

Pan XS. Analysis on the effect of garlicin for treating viral myocarditis. Youjiang Medical Journal 2010;38(2):120-122.

Chen, P. Y., Zhou, F., Chen, W. L., Ceng, Y., and Luo, L. Y. Clinical observation on the effect of Xinshu Capsule (XC) in treating frequent ventricular extrasystoles due to viral myocarditis and the influence on NO, NOS AND SOD [in Chinese]. Chinese Journal of Current Traditional and Western Medicine 2005;3(10):893-895.

Li, L., Zhang, S. L., Zhong, X. L., Xu, L. L., and Duan, A. Y. Observation on therapeutic effect of Qingxinkangyan Yin Decoction in treating patients with CVB myocarditis and nursing strategy. Journal of Nursing (China) 2006;13(3):59-60.

Li, M. Thirty-eight cases of viral myocarditis treated by Sheng Yang Yi Xin decoction [in Chinese]. Shaanxi Journal of Traditional Chinese Medicine 2006;27(7):791-793.

Zheng, R. The double-blinding study on the effects of Compound recipe Qiang Qi pill in treating patients with VMC. 2005;1-72.

Zhou, Y. W and Zhang, Z. J. Observation of Huo Ming decoction in treatment of viral myocarditis. Chinese Journal of Misdiagnosis 2008;8(23):5584-5585.

Han, Y., Zhang, X. J., and Li, J. Y. 30 cases of infantile viral myocarditis treated by integrated Chinese and western drugs. Journal of Practical Traditional Chinese Medicine 2000;16(4):21.

He, P. and Yang, S. Z. Clinical observation on the effect of Radix Astragali in the treatment of viral myocarditis complicated with ventricular premature beat and in the regulation of immunologic function. Journal of Traditional Chinese Medicine and Chinese Materia Medica of Jilin 1995;15(2):7-8.

Li, Z. Y., Liu, B. G., and Liu, Y. M. Observation on viral myocarditis treated with Huangqi injection. Chinese Journal of Information on Traditional Chinese Medicine 1998;5(12):51.

Liu, S. S. Study of adjunct treatment of Astragali membranaceus for viral myocarditis. Clinical Focus 1997;12(14):657-658.

Ma, G. L., Wang, C. Y., and Diao, W. X. Clinical study on viral myocarditis treated with integrated Chinese and western medicine. Acta Chinese Medicine and Pharmacology 1998;26(1):9-10.

Ren, W., Zhu, H. W., and Zhang, D. Y. Clinical observation on effect of Radix Astragali treating 66 patients with viral myocarditis complicated with cardiac dysfunction. Chinese Journal of Critical Care Medicine 1991;11(3):38-40.

Cheng L, Zhang G, Zhou Y, Lu X, Zhang F, Ye H, Duan J. Systematic review and meta-analysis of 16 randomized clinical trials of radix astragali and its prescriptions for diabetic retinopathy. Evid Based Complement Alternat Med. 2013;2013:762783.

He H, Zhou X, Wang Q, Zhao Y. Does the couse of astragalus-containing Chinese herbal prescriptions and radiotherapy benefit to non-small-cell lung cancer treatment: a meta-analysis of randomized trials. Evid Based Complement Alternat Med. 2013;2013:426207.

Piao YL, Liang XC. Astragalus membranaceus injection combined with conventional treatment for viral myocarditis: a systematic review of randomized controlled trials. Chin J Integr Med. 2014 Oct;20(10):787-91.

Tong X, Xiao D, Yao F, Huang T. Astragalus membranaceus as a cause of increased CA19-9 and liver and kidney cysts: a case report. J Clin Pharm Ther. 2014 Oct;39(5):561-3.

Wang CC, Cheng KF, Lo WM, Law C, Li L, Leung PC, Chung TK, Haines CJ. A randomized, double-blind, multiple-dose escalation study of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) for moderate to severe menopausal symptoms and quality of life in postmenopausal women. Menopause. 2013 Feb;20(2):223-31.

Zhang HW, Lin ZX, Xu C, Leung C, Chan LS. Astragalus (a traditional Chinese medicine) for treating chronic kidney disease. Cochrane Database Syst Rev. 2014 Oct 22;10:CD008369.

Zhu C, Cao H, Zhou X, Dong C, Luo J, Zhang C, Liu J, Ling Y. Meta-analysis of the clinical value of danshen injection and huangqi injection in liver cirrhosis. Evid Based Complement Alternat Med. 2013;2013:842824.

Li X, Qu L, Dong Y, Han L, Liu E, Fang S, Zhang Y, Wang T. A review of recent research progress on the astragalus genus. Molecules. 2014 Nov 17;19(11):18850-80.

Yu SY, Ouyang HT, Yang JY, et al. Subchronic toxicity studies of Radix Astragali extract in rats and dogs. J Ethnopharmacol. 2007 Mar 21;110(2):352-5.

Liu CH, Tsai CH, Li TC, et al. Effects of the traditional Chinese herb Astragalus membranaceus in patients with poststroke fatigue: A double-blind, randomized, controlled preliminary study. J Ethnopharmacol. 2016;194:954-962. doi: 10.1016/j.jep.2016.10.058.

Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062.

Chang CW, Chen CY, Yen CC, Wu YT, Hsu MC. Repressed exercise-induced hepcidin levels after danggui buxue tang supplementation in male recreational runners. Nutrients. 2018;10(9). pii: E1318.

Cao A, He H, Wang Q, Li L, An Y, Zhou X. Evidence of Astragalus injection combined platinum-based chemotherapy in advanced nonsmall cell lung cancer patients: a systematic review and meta-analysis. Medicine (Baltimore) 2019;98(11):e14798.

Lin S, An X, Guo Y, et al. Meta-analysis of astragalus-containing traditional Chinese medicine combined with chemotherapy for colorectal cancer: efficacy and safety to tumor response. Front Oncol 2019;9:749.

Zhang, Shergis JL, Yang L, et al. Astragalus membranaceus (Huang Qi) as adjunctive therapy for diabetic kidney disease: an updated systematic review and meta-analysis. J Ethnopharmacol 2019;239:111921.